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Compartmentalized gene regulatory networks of wheat pathogenic fungus Fusarium graminearum
时间:2016-10-31 16:58    点击:   所属单位:计算机学院
讲座名称 Compartmentalized gene regulatory networks of wheat pathogenic fungus Fusarium graminearum
讲座时间 2016-11-01 14:00:00
讲座地点 主楼四区107
讲座人 郭立
讲座人介绍 个人简介:
2006年毕业于西北农林科技大学,2011年毕业于美国宾夕法尼亚州立大学植物病理系
2012年3月到2016年9月  在美国马塞诸塞大学(UMASS)从事生物信息学
讲座内容
摘要:Head blight caused by Fusarium graminearum threatens worldwide wheat production, resulting in both yield loss and mycotoxin contamination. We reconstructed the global F. graminearum gene regulatory network (GRN) from a large collection of transcriptomic data using Bayesian network inference, a machine learning algorithm. This GRN reveals connectivity between key regulators and their target genes. Focusing on key regulators, this network contains eight distinct but interwoven modules. Enriched for unique functions, such as cell cycle, DNA replication, transcription, translation and stress responses, each module exhibits distinct expression profiles. Evolutionarily, the F. graminearum genome can be divided into core regions shared with closely related species and variable regions harboring genes that are unique to F. graminearum and perform species-specific functions. Interestingly, the inferred top regulators regulate genes that are significantly enriched from the same genomic regions (P < 0.05), revealing a compartmentalized network structure that may reflect network rewiring related to specific adaptation of this plant pathogen. This first-ever reconstructed filamentous fungal GRN primes our understanding of pathogenicity at the systems biology level and provides enticing prospects for novel disease control strategies involving the targeting of master regulators in pathogens. 
 
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